菜单 基因医生

该基因属于酪氨酸蛋白激酶家族的肾上腺素受体亚家族。eph和eph相关受体参与了发育事件的调节,特别是在神经系统中。eph亚家族的受体通常有一个单一的激酶结构域和一个胞外区域,包含一个富含cys的结构域和2个纤维连接蛋白iii型重复序列。根据其胞外结构域序列的相似性和结合ephrin-a和ephrin-b配体的亲和力,ephrin受体可分为两类。这个基因编码一种结合肾上腺素a配体的蛋白质。已经描述了该基因的两个选择性剪接转录变体。[由RefSeq提供,2008年7月]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

基因名:EPHA3
别名:EK4,ETK,HEK,ETK1,HEK4,TYRO4
基因ID:2042
Chromosome:
(GRCh37)
3 Start: 89156674 End: 89531284 Strand: 
信号通路: 细胞增殖 
EPHA3 基因突变与药物