产品概述

基于新一代高通量测序(NGS)技术,一次性检测962个肿瘤精准用药相关基因,包括854个药物靶点基因,耐药及预后相关基因,原癌及抑癌基因,高频突变基因,肿瘤信号通路基因;114个肿瘤遗传易感基因;38个化疗药物疗效相关位点;同时可多维度预测免疫治疗疗效(TMB、MSI及PD-L1表达),更加精准的评估基因突变与靶向用药、化疗药物、免疫药物的相关性,指导个体化诊断和治疗,为患者提供更多生存获益的可能。

产品特点

1.多维治疗方案依据:从靶向治疗到化疗、免疫方案的选择,为多药联合治疗提供依据;
2.全面免疫治疗评估:PD-L1表达、TMB、MSI、HLA综合评估,免疫相关通路正负调节基因及预后相关基因全覆盖,免疫治疗一步到位 ;
3.精准用药指导:涵盖NCCN指南、FDA/NMPA批准及临床试验250多种靶向药物及18种化疗药物26种治疗方案,全面指导 精准用药 ;
4.遗传风险评估:114个遗传易感基因,涵盖20种遗传性肿瘤,综合评估遗传风险 ;

适用人群

1.需要个体化靶向药物、免疫药物、化疗药物治疗的实体瘤患者;2.典型驱动基因突变为阴性,寻求更多靶向用药机会的实体瘤患者;3.原发灶不明、全身多发肿瘤或转移的实体瘤患者;4.耐药后,寻求耐药机制及有效药物的实体瘤患者;5.有肿瘤家族史的实体瘤患者;

检测基因

A1CF ABCB1  ABCC4  ABCG2  ABI1 ABL1  ABL2  ACKR3 ACSL3  ACSL6 ACVR1  ACVR1B  ACVR2A  ADH1B  AFF1  AFF3  AKAP9  AKT1  AKT2  AKT3  ALDH2  ALK  ALOX12B  AMER1  ANK1 ANKRD11  APC  APOBEC3B  AR  ARAF  ARFRP1  ARHGAP26  ARHGAP5 ARHGEF10 ARHGEF10L ARHGEF12 ARID1A  ARID1B  ARID2  ARID3C ARID4A  ARID4B  ARID5A ARID5B  ARNT  ASPSCR1  ASXL1  ASXL2  ATIC  ATM  ATP1A1  ATP2B3  ATP6AP1 ATP6V1B2 ATR  ATRX  ATXN2 AURKA  AURKB  AXIN1  AXIN2  AXL  B2M  BABAM1  BACH2 BAP1  BARD1  BAX  BAZ1A BCL10  BCL11A  BCL11B  BCL2  BCL2L1  BCL2L11  BCL2L12 BCL2L2  BCL3  BCL6  BCL7A BCL9  BCL9L BCLAF1  BCOR  BCORL1  BCR  BIRC3  BIRC6 BLM  BMP5 BMPR1A  BRAF  BRCA1  BRCA2  BRD3  BRD4  BRIP1  BTG1  BTG2  BTK  BUB1B  C11orf30 C17orf39 C2orf44 C8orf34  CACNA1D  CALR  CAMTA1  CANT1 CARD11  CARM1  CARS CASC5 CASP3 CASP8  CASP9  CBFA2T3  CBFB  CBL  CBLB  CBLC  CBR3  CCDC6  CCNB1IP1 CCND1  CCND2  CCND3  CCNE1  CCR4  CCR7 CD209 CD22  CD274  CD276  CD28 CD58 CD70  CD74  CD79A  CD79B  CDA  CDC42  CDC73  CDH1  CDH10  CDH11  CDH17 CDK12  CDK4  CDK6  CDK8  CDKN1A  CDKN1B  CDKN2A  CDKN2B  CDKN2C  CDX2  CEBPA  CEP89 CHD2   CHD4  CHEK1  CHEK2  CHIC2 CHST11 CIC  CIITA  CLIP1 CLTC  CLTCL1  CNBD1 CNOT3  CNTNAP2  CNTRL COL1A1  COL2A1  COL3A1 COX6C CPEB3 CREB3L1  CREB3L2  CREBBP  CRKL  CRLF2  CRNKL1  CRTC1  CRTC3 CSDE1  CSF1R  CSF3R  CSMD3  CTCF  CTLA4  CTNNA1  CTNNA2  CTNNB1  CTNND1  CTNND2  CUL3  CUL4A  CUX1  CXCR4  CYLD  CYP17A1  CYP19A1  CYP2B6  CYP2C8  CYP2D6  DAXX  DCAF12L2  DCC  DCTN1 DCUN1D1  DDB2  DDIT3  DDR1  DDR2  DDX10 DDX3X  DDX5  DDX6 DEK  DGCR8 DHFR  DICER1  DIS3  DNAJB1  DNM2  DNMT1  DNMT3A  DNMT3B  DOTIL DPYD  DROSHA  DTX1  DUSP22  DUSP4  DUX4L1 DYNC2H1  E2F3  EBF1  ECT2L  EED  EGFR  EGR1 EIF1AX  EIF3E EIF4A2  EIF4E  ELF3  ELK4 ELL  ELN  EML4  EP300  EP400 EPAS1  EPCAM  EPHA2  EPHA3  EPHA5  EPHA7  EPHB1  EPHB2  EPHB4  EPS15  ERBB2  ERBB3  ERBB4  ERC1 ERCC1  ERCC2  ERCC3  ERCC4  ERCC5  ERF  ERG  ERRFI1  ESCO2 ESR1  ETNK1 ETS2  ETV1  ETV4  ETV5  ETV6  EWSR1  EXT1  EXT2  EZH1  EZH2  EZR  FAM131B  FAM135B  FAM175A  FAM46C  FAM47C FANCA  FANCC  FANCD2  FANCE  FANCG  FANCL  FAS  FAT1  FAT3  FAT4  FBLN2 FBXO11  FBXW7  FCGR2A  FCGR2B  FCGR3A  FCRL4  FES  FGF10  FGF12  FGF14  FGF19  FGF23  FGF3  FGF4  FGF6  FGFR1  FGFR1OP FGFR2  FGFR3  FGFR4  FH  FHIT  FIP1L1  FKBP9 FLCN  FLI1  FLNA  FLT1  FLT3  FLT4  FNBP1 FOXA1  FOXL2  FOXO1  FOXO3  FOXO4  FOXP1  FSTL3 FUBP1  FURIN FUS  FYN  GABRA6  GAS7 GATA1  GATA2  GATA3  GATA6  GGH  GID4  GLI1  GMPS  GNA11  GNA12  GNA13  GNAQ  GNAS  GNB1 GOLGA5 GOPC  GPC3  GPC5 GPHN GPS2  GREM1  GRIN2A  GRM3  HDAC4  HDAC1  H3f3c  H3F3B  H3F3A  GTF2I GSTP1  GSK3B  HGF  HIST1H1B HIFIA HEY1  HERC2  HDAC7  HIP1  HIST1H1C  HIST1H3C  HIST1H3B  HIST1H1E  Hist1h2bo  HIST1H2BK HIST1H2BD  Hist1h2bc  HIST1H2BG HLA-A  HIST3H3  HIST2H3D  HIST1H4I  HIST1H3I  HIST1H3H  HIST1H3E  HIST1H3D  HNRNPA2B1 HNF1A  HLF  HLA-C  HLA-B  HOXA11  HOXA9  HOXA13  HOXD11  HOXC11 HOXB13  HOXC13  ICOSLG  ID3  IDH1  IDH2  IKZF1  IKBKB  IGF2BP2 IKBKE  HRAS  HSD3B1  HSP90AB1  HSP90AA1  IFNGR1  IGF1  IGF1R  IGF2  IL10  IL6ST  IL21R  IKZF3  INHA  IL7R  INPP4A  INPP4B  INPPL1  INSR  IRF2  INHBA  IRF8  IRF4  IRS2  IRS1  IRS4 ISX ITK  ITGAV JAK2  JAK1  JARID2  JAK3  KDM5C  KDM5A  KDM6A  KDR  KAT6B  JUN  KCNJ5  KAT7 KEAP1  KDSR KIAA1549  KEL  KLF4  KIT  KIF5B  KIAA1598 KLF5  KLHL6  KMT2A  KLK2 KMT2D  KMT2C  KNSTRN  KRAS  LARP4B LASP1  KTN1 KSR2 LCK  LCP1  LEF1  LATS2  LMO1  LMNA LMO2 LPP  LRIG3  LRP1B  LTK  LIFR  LHFP LYN  LSM14A LTB MACC1 LZTR1  MAF  MALAT1 MAPK1  MAP3K13  MAP3K1  MAP3K14  MDM2  MDC1  MDM4  MECOM  MGAM MITF  MGA  MET  MAP2K1  MAML2  MAP2K2  MAP2K4  MAPKAP1  MAX  MCL1  MB21D2  MEN1  MEF2B  MED12  MERTK  MKNK1  MKL1 MLH1  MLF1 MLLT1  MLH3  MLLT10 MLLT11 MPEG1 MPL  MRE11A  MSH2  MTHFR  MTAP  MST1R  MST1  MYB  MUC4 MUC16  MUTYH  MN1  mllt4  MLLT3  MLLT6  MSN  MSH6  MSH3  MSI1  MTOR  MTR  MUC1  MTRR  MYCL  MYC  MYCN  MYD88  MYH9  MYOD1  MYH11  MYO5A NCOA2  NBN  NCOA1 NCKIPSD NCSTN  NEGR1  NEK8 NF1  NFKB2 NFIB NFKBIE NFKBIA  NAB2  N4BP2 NBEA NACA NCOR1  NCOR2  NCOA4  NCOA3  NFATC2  NF2  NIN  NFE2L2  NFE2 NONO  NKX2-1  NKX3-1  NOTCH2  NOTCH1  NOTCH4  NOTCH3  NPM1  MQO1 NR4A3  NRAS  NT5C2  NRG1  NSD1  NTRK1  NTRK2  NTRK3  NUF2  NUMA1  NUP214 NUP93  NUP98  NUTM1  NUTM2B OLIG2 OMD  PABPC1  P2RY8  PAK1  PAFAH1B2 Pak7  PARP1  PARK2  PALB2  PARP3  PARP2  PAX3  PAX5  PCM1 PDCD1  PER1  PGR  PCBP1  PDCD1LG2  PDS5B PDPK1  PIK3C2G  PIK3C2B  PIK3CA  PIK3C3  PAX8  PAX7  PBX1  PBRM1  PDK1  PDGFRA  PDE4DIP  PDGFRB  PHOX2B  PHF6  PIGA PICALM PIK3CD  PIK3CB  PIK3R1  PIK3CG  PIK3R2  PLAG1  PIM1  PIK3R3  POLD1  PMS2  PMS1  PNRC1  POU5F1  PPM1D  PPARG  POU2AF1  PRDM1  PRCC  PRDM16  PRDM14  PLCG2  PLCG1  PLK2  PML  POLG  POLE  POLQ  POT1  PPP2R2A  PPP4R2  PPP6C  PPP2R1A  PRF1  PREX2  PRDM2 PRKACA  PRKAR1A  PRKCB  PRKD1  PRKCI  PTEN  PTPN1 PTCH1  PTPN11  PTPRC PTPRD  PTPRO  PTPRK  RAD21  RAD17 RABEP1 RAC1  PRPF40B  PRRX1  PSIP1  PRSS1  PTPN2  PTPN13  PTPN6  PTPRB  QKI  PTPRT  PTPRS  PWWP2A RAD50  RAD51  RAD51C  RAD51B  RAD52  RAD51D  RAF1  RAD54L  RBM10  RB1  RECQL  RBM15 RFWD2 RGS7 RGPD3  RFWD3 RNF213  RIT1  ROBO1  RNF43  RALGDS RANBP2  RASA1  RARA  RECQL4  RELN  RET  REL  RHEB  RHOH  RHOA  RICTOR  RPL10 ROS1  ROCK1  ROBO2  RPS6KA4  RPN1 RPL5  RPL22  RSPO2  RSPO3  RRM1  RRAS2  S100A7 SALL4 RYBP  RXRA  SDHB  SDHC  SEPT6 SDHD  SETD1A SETD1B SETD4 SETD2  SETDB2 SETDB1  SF3B2 SF3B1  RPS6KB2  RPTOR  RQCD1 RRAS  RUNDC2A RTEL1  RUNX1T1  RUNX1  SDC4  SBDS  SDHAF2  SDHA  Sept9  SESN2  SETBP1  SESN3  SETD6 SETD5 SETD8 SETD7 SFPQ  SFRP4 SH2B3  SGK1  SIX1  SH2D1A  SH3GL1 SIRPA SLIT1  SMAD2  SLX4  SLC45A3  SMG1 SMC3  SMARCD1  SMC1A  SOD2  SOCS1  SOX17  SOS1  SPOP  SPEN  SPECC1 SPRED1  STAG1  SSX1  SS18L1 SS18  SIX2 SKI SLC22A16  SLC34A2  SMAD4  SMAD3  SMARCB1  SMARCA4  SNCAIP  SND1 SP140 SOX9  SRSF2  SRSF3 SMYD3  SMO  SOX21  SOX2  SRC  SRGAP3  STAG2  STAT3  STAT5B  STAT5A  STIL STAT6  STK33 STK11  TAF15  SYK  TAL1  TAL2 TCF12  TCF7L2  TCF3  TCEB1  TET2  TERT  TET3 TFE3  THRAP3  TLX1 TIPARP  TGFBR2  TP53  TOP1  TNFRSF17  TNFRSF14  STRN STK40  SUZ12  SUFU  TBL1XR1  TAP1  TCEA1 TBX3  TCL1A  Tec  TERC  TEK  TFG  TFRC TFEB TGFBR1  TNFAIP3  TNC TMEM127  TMPRSS2  TP63  TRAF2  TPR  TP53BP1  TRAF3 TRAF5  TRAF7  TRIM24  TRIM33 TRIP11 TRRAP  TSC1  TSC2  TSHR  TTK TYK2  TYRO3  U2AF1  U2AF2 UBR5  UGT1A1  UMPS  UPF1  USP44 USP6  USP8  VAV1 VAV2 VEGFA  VHL  VTCN1  VTI1A WAS  WHSC1  WHSC1L1  WNK2 WRN  WT1  WWTR1  XIAP  XPC  XPO1  XRCC1  XRCC2  YAP1  YES1  ZBTB16  ZCCHC8 ZEB1  ZFHX3  ZMYM3  ZNF198 ZNF217  ZNF278 ZNF331 ZNF384  ZNF429 ZNF479 ZNF521  ZNF703  ZNRF3  ZRSR2 

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