菜单 基因医生

这个基因编码bcl-2蛋白家族的一个成员。这个家族的蛋白质形成异二聚体或同二聚体,并作为抗和促凋亡的调节因子。在细胞毒性条件下,该基因在细胞中的表达有助于减少细胞凋亡。对小鼠相关基因的研究表明,ngf和bdnf依赖神经元的存活与此有关。小鼠基因的突变和敲除研究表明在成年精子发生中起着重要作用。选择性剪接导致多个转录变体。该基因与邻近的下游pabpn1(poly(a)结合蛋白,nuclear 1)基因之间也存在读写转录。[由RefSeq提供,2010年12月]
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

基因名:BCL2L2
别名:BCLW,BCL-W,PPP1R51,BCL2-L-2
基因ID:599
Chromosome:
(GRCh37)
14 Start: 23775971 End: 23790241 Strand: 
信号通路: 凋亡抑制 
BCL2L2 基因突变与药物