菜单 基因医生

肾上腺素受体及其配体,即肾上腺素,介导许多发育过程,特别是在神经系统。根据它们的结构和序列关系,肾上腺素可分为通过糖基磷脂酰肌醇键固定在膜上的肾上腺素-A(EFNA)类和跨膜蛋白肾上腺素-B(EFNB)类。eph受体家族根据其胞外结构域序列的相似性和与ephrin-a和ephrin-b配体结合的亲和力可分为2类。肾上腺素受体是酪氨酸激酶(rtk)受体家族中最大的亚群。这个基因编码的蛋白质是肾上腺素b家族成员的受体。[由RefSeq提供,2008年7月]
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

基因名:EPHB1
别名:ELK,NET,Hek6,EPHT2
基因ID:2047
Chromosome:
(GRCh37)
3 Start: 134514099 End: 134979309 Strand: 
信号通路: 细胞增殖 
EPHB1 基因突变与药物