菜单 基因医生

组蛋白在转录调控、细胞周期进展和发育事件中起着关键作用。组蛋白乙酰化/去乙酰化改变染色体结构并影响转录因子对dna的获取。该基因编码的蛋白属于组蛋白去乙酰化酶/acuc/apha家族的Ⅱ类。它具有组蛋白脱乙酰酶活性,当与启动子结合时抑制转录。这种蛋白质不直接与dna结合,而是通过转录因子mef2c和mef2d,它似乎与rbap48和hdac3在多蛋白复合物中相互作用。[由RefSeq提供,2008年7月]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

基因名:HDAC4
别名:HD4,AHO3,BDMR,HDACA,HA6116,HDAC-4,HDAC-A
基因ID:9759
Chromosome:
(GRCh37)
2 Start: 239969864 End: 240323346 Strand: 
信号通路:  
HDAC4 基因突变与药物