菜单 基因医生

干扰素一致性序列结合蛋白(icsbp)是干扰素(ifn)调节因子(irf)家族的一个转录因子。这个家族的蛋白质由n-末端的保守dna结合区和作为调控区的发散c-末端区组成。irf家族蛋白与ifn刺激反应元件(isre)结合,调节i型ifn刺激的基因表达,即ifnα和ifnβ。irf家族蛋白还控制病毒感染诱导的ifnα和ifnβ调节基因的表达。[由RefSeq提供,2008年7月]
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

基因名:IRF8
别名:ICSBP,IRF-8,ICSBP1,IMD32A,IMD32B,H-ICSBP
基因ID:3394
Chromosome:
(GRCh37)
16 Start: 85932774 End: 85956212 Strand: 
信号通路:  
IRF8 基因突变与药物