菜单 基因医生

这个基因编码一个R-反应蛋白家族的成员。这些蛋白是富含亮氨酸重复序列的分泌配体,含有g蛋白偶联受体,通过抑制泛素e3连接酶增强wnt信号传导。在多种人类癌症中,包括这个基因座在内的染色体易位导致了基因融合的形成。选择性剪接导致多个转录变体。[由RefSeq提供,2015年12月]
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

基因名:RSPO2
别名:HHRRD,TETAMS2,CRISTIN2
基因ID:340419
Chromosome:
(GRCh37)
8 Start: 108911544 End: 109095913 Strand: 
信号通路:  
RSPO2 基因突变与药物