菜单 基因医生

该基因编码一种多功能促炎细胞因子,属于肿瘤坏死因子(TNF)超家族。这种细胞因子主要由巨噬细胞分泌。它能与受体TNFRSF1A/TNFR1和TNFRSF1B/TNFBR结合并通过其发挥作用。这种细胞因子参与调节广泛的生物学过程,包括细胞增殖、分化、凋亡、脂质代谢和凝血。这种细胞因子与多种疾病有关,包括自身免疫性疾病、胰岛素抵抗和癌症。小鼠的基因敲除研究也表明了这种细胞因子的神经保护作用。[由RefSeq提供,2008年7月]
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

基因名:TNF
别名:DIF,TNFA,TNFSF2,TNLG1F,TNF-alpha
基因ID:7124
Chromosome:
(GRCh37)
6 Start: 31543344 End: 31546113 Strand: 
信号通路: 细胞增殖  免疫相关  炎症相关  凋亡抑制 
TNF 基因突变与药物