菜单 基因医生

这个基因编码的蛋白质是肿瘤坏死因子受体超家族的一员。该受体在成熟的b淋巴细胞中优先表达,可能对b细胞的发育和自身免疫反应具有重要意义。该受体与肿瘤坏死因子(配体)超家族成员13b(TNFSF13B/TALL-1/BAFF)特异性结合,导致NF-kappaB和MAPK8/JNK活化这种受体还与traf家族的不同成员结合,因此可以传递细胞生存和增殖的信号。[由RefSeq提供,2008年7月]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

基因名:TNFRSF17
别名:BCM,BCMA,CD269,TNFRSF13A
基因ID:608
Chromosome:
(GRCh37)
16 Start: 12058964 End: 12061925 Strand: 
信号通路:  
TNFRSF17 基因突变与药物